Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Tanzanian Children (PEE TB Study)

Low anti-TB drug concentrations in blood are associated with inferior treatment outcomes, including treatment failure and relapse. Urine colorimetry provides a low-technology approach for measuring anti-TB drug exposures, suitable for point-of-care testing.

Principal Investigator

Funder

Study Duration

Enhanced Tuberculosis Active Case Finding among Household Contacts in Haydom, Tanzania (ACF Study)

TB remains a large public health threat in Tanzania. Household contact screening is essential to identify children under 15 at risk for active TB or latent TB infection.

Principal Investigator

Funder

Study Duration

Diversity of Etiologies and Outcomes of Acute Febrile Illness in Rural Tanzania (AFI_Rural Tanzania)

AFI is a common reason for hospital admission in low-resource settings, but diagnostics are limited. This study uses PCR and serology to characterize causes and clinical outcomes of AFI in Haydom, Tanzania.

Principal Investigator

Funder

Study Duration

Stool Testing for Alternative Rapid-Diagnosis of TB (START Study)

This study evaluates whether routine stool TB testing using Xpert MTB Ultra improves early detection of TB among children hospitalized with pneumonia or severe acute malnutrition.

Principal Investigator

Funder

Study Duration

Point-of-care Evaluation of Exposure to TB drugs – PEE-TB: Precision Rifampin (P-Rif) Trial

Urine spectrophotometry identifies patients with below-target rifampin concentrations for dose adjustment. The trial assesses efficacy and safety of dose adjustment among adults and children with drug-sensitive pulmonary TB.

Principal Investigator

Funder

Study Duration

Investigation into the Etiology of Severe Acute Malnutrition in Children Across Southern and Eastern Africa (KwashNet Study)

This study investigates genetic and epigenetic mechanisms differentiating kwashiorkor and marasmus in children to improve treatment and prevention strategies for severe acute malnutrition.

Principal Investigator

Funder

Study Duration